Advanced Radio Resource Management for Multi Antenna Packet Radio Systems

In this paper, we propose fairness-oriented packet scheduling (PS) schemes with power-efficient control mechanism for future packet radio systems. In general, the radio resource management functionality plays an important role in new OFDMA based networks. The control of the network resource division among the users is performed by packet scheduling functionality based on maximizing cell coverage and capacity satisfying, and certain quality of service requirements. Moreover, multiantenna transmit-receive schemes provide additional flexibility to packet scheduler functionality. In order to mitigate inter-cell and co-channel interference problems in OFDMA cellular networks soft frequency reuse with different power masks patterns is used. Stemming from the earlier enhanced proportional fair scheduler studies for single-input multiple-output (SIMO) and multiple-input multipleoutput (MIMO) systems, we extend the development of efficient packet scheduling algorithms by adding transmit power considerations in the overall priority metrics calculations and scheduling decisions. Furthermore, we evaluate the proposed scheduling schemes by simulating practical orthogonal frequency division multiple access (OFDMA) based packet radio system in terms of throughput, coverage and fairness distribution among users. As a concrete example, under reduced overall transmit power constraint and unequal power distribution for different sub-bands, we demonstrate that by using the proposed power-aware multi-user scheduling schemes, significant coverage and fairness improvements in the order of 70% and 20%, respectively, can be obtained, at the expense of average throughput loss of only 15%.Comment: 14 Pages, IJWM

Fairness-Oriented and QoS-Aware Radio Resource Management in OFDMA Packet Radio Networks: Practical Algorithms and System Performance

During the last two decades, wireless technologies have demonstrated their importance in people’s personal communications but also as one of the fundamental drivers of economic growth, first in the form of cellular networks (2G, 3G and beyond) and more recently in terms of wireless computer networks (e.g. Wi-Fi,) and wireless Internet connectivity. Currently, the development of new packet radio systems is evolving, most notably in terms of 3GPP Long Term Evolution (LTE) and LTE-Advanced, in order to utilize the available radio spectrum as efficiently as possible. Therefore, advanced radio resource management (RRM) techniques have an important role in current and emerging future mobile networks. In all wireless systems, the data throughput and the average data delay performance, especially in case of best effort services, are greatly degraded when the traffic-load in the system is high. This is because the radio resources (time, frequency and space) are shared by multiple users. Another big problem is that the transmission performance can vary heavily between different users, since the channel state greatly depends on the communication environment and changes therein. To solve these challenges, new major technology innovations are needed. This thesis considers new practical fairness-oriented and quality-of-service (QoS) -aware RRM algorithms in OFDMA-based packet radio networks. Moreover, using UTRAN LTE radio network as application example, we focus on analyzing and enhancing the system-level performance by utilizing state-of-the-art waveform and radio link developments combined with advanced radio resource management methods. The presented solutions as part of RRM framework consist of efficient packet scheduling, link adaptation, power control, admission control and retransmission mechanisms. More specifically, several novel packet scheduling algorithms are proposed and analyzed to address these challenges. This dissertation deals specifically with the problems of QoS provisioning and fair radio resource distribution among users with limited channel feedback, admission and power control in best effort and video streaming type traffic scenarios, and the resulting system-level performance. The work and developments are practically-oriented taking aspects like finite channel state information (CSI), reporting delays and retransmissions into account. Consequently, the multi-user diversity gain with opportunistic frequency domain packet scheduling (FDPS) is further explored in spatial domain by taking the multiantenna techniques and spatial division multiplexing functionalities into account. Validation and analysis of the proposed solutions is performed through extensive system level simulations modeling the behavior and operation of a complete multiuser cell in the overall network. Based on the obtained performance results, it is confirmed that greatly improved fairness can be fairly easily built in to the scheduling algorithm and other RRM mechanisms without considerably degrading e.g. the average cell throughput. Moreover, effective QoS-provisioning framework in video streaming type traffic scenarios demonstrate the effectiveness of the presented solutions as increased system capacity measured in terms of the number of users or parallel streaming services supported simultaneously by the network

Canagliflozin and Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus and Chronic Kidney Disease in Primary and Secondary Cardiovascular Prevention Groups

Background: Canagliflozin reduces the risk of kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, but effects on specific cardiovascular outcomes are uncertain, as are effects in people without previous cardiovascular disease (primary prevention). Methods: In CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation), 4401 participants with type 2 diabetes mellitus and chronic kidney disease were randomly assigned to canagliflozin or placebo on a background of optimized standard of care. Results: Primary prevention participants (n=2181, 49.6%) were younger (61 versus 65 years), were more often female (37% versus 31%), and had shorter duration of diabetes mellitus (15 years versus 16 years) compared with secondary prevention participants (n=2220, 50.4%). Canagliflozin reduced the risk of major cardiovascular events overall (hazard ratio [HR], 0.80 [95% CI, 0.67-0.95]; P=0.01), with consistent reductions in both the primary (HR, 0.68 [95% CI, 0.49-0.94]) and secondary (HR, 0.85 [95% CI, 0.69-1.06]) prevention groups (P for interaction=0.25). Effects were also similar for the components of the composite including cardiovascular death (HR, 0.78 [95% CI, 0.61-1.00]), nonfatal myocardial infarction (HR, 0.81 [95% CI, 0.59-1.10]), and nonfatal stroke (HR, 0.80 [95% CI, 0.56-1.15]). The risk of the primary composite renal outcome and the composite of cardiovascular death or hospitalization for heart failure were also consistently reduced in both the primary and secondary prevention groups (P for interaction >0.5 for each outcome). Conclusions: Canagliflozin significantly reduced major cardiovascular events and kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, including in participants who did not have previous cardiovascular disease

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

InDEx – Industrial Data Excellence

InDEx, the Industrial Data Excellence program, was created to investigate what industrial data can be collected, shared, and utilized for new intelligent services in high-performing, reliable and secure ways, and how to accomplish that in practice in the Finnish manufacturing industry.InDEx produced several insights into data in an industrial environment, collecting data, sharing data in the value chain and in the factory environment, and utilizing and manipulating data with artificial intelligence. Data has an important role in the future in an industrial context, but data sources and utilization mechanisms are more diverse than in cases related to consumer data. Experiences in the InDEx cases showed that there is great potential in data utili zation.Currently, successful business cases built on data sharing are either company-internal or utilize an existing value chain. The data market has not yet matured, and third-party offerings based on public and private data sources are rare. In this program, we tried out a framework that aimed to securely and in a controlled manner share data between organizations. We also worked to improve the contractual framework needed to support new business based on shared data, and we conducted a study of applicable business models. Based on this, we searched for new data-based opportunities within the project consortium. The vision of data as a tradeable good or of sharing with external partners is still to come true, but we believe that we have taken steps in the right direction.The program started in fall 2019 and ended in April 2022. The program faced restrictions caused by COVID-19, which had an effect on the intensity of the work during 2020 and 2021, and the program was extended by one year. Because of meeting restrictions, InDEx collaboration was realized through online meetings. We learned to work and collaborate using digital tools and environments. Despite the mentioned hindrances, and thanks to Business Finland’s flexibility, the extension time made it possible for most of the planned goals to be achieved.This report gives insights in the outcomes of the companies’ work within the InDEx program. DIMECC InDEx is the first finalized program by the members of the Finnish Advanced Manufacturing Network (FAMN, www.famn.fi).</p

Effect of high-velocity scenarios on the performance of MIMO LTE packet scheduling

In this paper we analyze the performance of advanced OFDM packet scheduling techniques based on 3GPP UTRAN Long Term Evolution (LTE) framework for high velocity scenarios. Based on our previous investigations in system performance analysis, we demonstrate that packet scheduler being part of the whole radio resource management (RRM) process has a major impact on it. On the other hand high user velocities further imply additional system performance limitations due to the introduction of reporting overhead. Therefore, we investigate the resulting fairness distribution among users together with the achievable radio system performance in terms of throughput, coverage and fairness distribution, by simulating practical OFDMA cellular system environment with MIMO functionality in Macro cell Best effort traffic scenario. As a concrete example, we demonstrate that by using the advanced fairness-oriented multi-user scheduling schemes, significant coverage improvements in the order of 30% can be obtained by achieving the same cell throughput. Furthermore, the user fairness is also greatly increased, by more than 25%, when measured using Jain's fairness index. 2011 IEEE.Scopu

Advanced packet scheduling for efficient video support with limited channel feedback on MIMO LTE downlink

Next-generation mobile networks will provide users with high data rates, increased mobility and various services. The initial step made in LTE and LTE-A is adopting the OFDM(A) air interface and utilization of dynamic resource allocation techniques maximizing the cell throughput and coverage as part of enhanced radio resource management functionality. Moreover, the control of the network resource division among users is performed by packet scheduler and different scheduling strategies are applied according to traffic scenario. Typically, video traffic (real-time video streaming, mobile TV etc.) requires higher data rates and certain quality of service (QoS) constrains, i.e. packet size, arrival rate, head-of-line (HOL) packet delay, etc. In this article, we propose a flexible and fairness-oriented packet scheduling approach for real-time video delivery, built on advanced QoS-aware multiuser proportional fair (PF) scheduling principle. Special emphasis is put on practical feedback reporting schemes, including the effects of mobile measurements and estimation errors, reporting delays, and feedback quantization and compression. The performance of the overall scheduling and feedback reporting process is investigated in details in terms of cellular system capacity, resource allocation fairness and video traffic QoS guarantees. Experimental results reveal the bounds of real-time video traffic support on LTE downlink. 2011 IEEE.Scopu

Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease: Results From the CREDENCE Trial and Meta-Analysis

BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus.METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-analysis.RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (&lt;45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]).CONCLUSIONS: Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02065791